Immediate and persisting dose related Psilocybin effects

Rationale: Psilocybin effects study extends previous observations showing that psilocybin can occasion mystical-type experiences having persisting positive effects on attitudes, mood, and behavior. Objectives: This double-blind study evaluated psilocybin (0, 5, 10, 20, 30 mg/70 kg, p.o.) administered under supportive conditions. Methods: Participants were 18 adults (17 hallucinogen-naïve). Five 8-hour sessions were conducted individually for […]

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Psilocybin for depression and anxiety

Cancer patients often develop chronic, clinically significant symptoms of depression and anxiety. Previous studies suggest that psilocybin may decrease depression and anxiety in cancer patients. The effects of psilocybin were studied in 51 cancer patients with life-threatening diagnoses and symptoms psilocybin for depression and/or anxiety. This randomized, double-blind, cross-over trial investigated the effects of a

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Effects of Psilocybin Therapy on Major Depressive Disorder

Importance: Major depressive disorder (MDD) is a substantial public health burden, but current treatments have limited effectiveness and adherence. Recent evidence suggests that 1 or 2 administrations of psilocybin therapy with psychological support produces antidepressant effects in patients with cancer and in those with treatment-resistant depression. Objective To investigate the effect of psilocybin therapy in

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MDMA Assisted psychotherapy for treatment of PTSD

Study design and rationale for phase 3 trials based on pooled analysis of six phase 2 randomized controlled trials Background: Posttraumatic stress disorder is a prevalent mental health condition with substantial impact on daily functioning that lacks sufficient treatment options. Here we evaluate six phase 2 trials in a pooled analysis to determine the study

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MDMA Assisted Psychotherapy for PTSD

Long-term follow-up outcomes of MDMA Assisted Psychotherapy for treatment of PTSD: a longitudinal pooled analysis of six phase 2 trials Rationale: Posttraumatic stress disorder (PTSD) is a chronic condition that has wide-ranging negative effects on an individual’s health and interpersonal relationships. Treatments with long-term benefits are needed to promote the safety and well-being of those

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